Skin Care: Scar-free Healing Shown With Gene Suppression

New research from the University of Bristol shows that by suppressing one of the genes that normally switches on in wound cells, wounds can heal faster and reduce scarring. This has major implications not just for wound victims but also for people who suffer organ tissue damage through illness or abdominal surgery.

When skin is damaged a blood clot forms and cells underneath the wound start to repair the damage, leading to scarring. Scarring is a natural part of tissue repair and is most obvious where skin has healed after a cut or burn. It ranges from trivial (a grazed knee) to chronic (diabetic leg ulcers) and is not limited to the skin. All tissues scar as they repair; for example, alcohol-induced liver damage leads to fibrosis and liver failure, and after most abdominal surgeries scars can often lead to major complications.

Tissue damage triggers an inflammatory response by white cells to protect skin from infection by killing microbes. The same white cells guide the production of layers of collagen. These layers of collagen help the wound heal but they stand out from the surrounding skin and result in scarring. Research by Professor Paul Martin and colleagues at the University of Bristol shows that osteopontin (OPN) is one of the genes that triggers scarring and that applying a gel, which suppresses OPN to the wound, can accelerate healing and reduces scarring. It does this in part by increasing the regeneration of blood vessels around the wound and speeding up tissue reconstruction.

Speaking of the discovery, Professor Martin said: ‘White blood cells (macrophages), and the chemical signals (PDGF) delivered to the wound cells, and osteopontin itself are now all clear targets for developing medicines to improve healing of skin wounds and other organs where fibrotic tissue repair can be debilitating. We hope that it won’t be too long before such therapies are available in the clinic. Indeed, the technique for suppressing OPN to reduce scarring is currently being licensed and patented by a Biotech company specializing in wound-healing therapies.’

Earlier research by Professor Martin’s lab and others has shown that embryos of many species, including humans, heal wounds without leaving a scar. Now it looks like the same may be true for adults.

The findings will be published by the Journal of Experimental Medicine on 26 January in a paper entitled ‘Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring’. The paper is currently available online

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European Birds Flock To Warming Britain, While Some Northern Species Not Faring As Well

Researchers at Durham, the RSPB and Cambridge University have found that birds such as the Cirl Bunting and Dartford Warbler are becoming more common across a wide range of habitats in Britain as temperatures rise.

Unfortunately, some northern species, such as the Fieldfare and Redwing, are not faring quite so well and their numbers are falling.

Researchers looked at twenty-five year population trends of 42 bird species in relation to changes in climatic suitability simulated using climatic envelope models.

Professor Brian Huntley from The Institute of Ecosystem Science at Durham University says: "The results are what we expected to find given the changes in climate over the last 20 years.

"Because the UK is in the middle Latitudes of Europe, we expected that recent climatic warming would favour species with ranges located in the south of Europe and adversely affect northern species."

Bird spotters may have to refer to new books to identify some of the new visitors to our shores but Britons who've visited the Mediterranean region may recognise the increasing presence of the famously explosive song of Cetti's Warbler.

Northern species that are under threat also include the Slavonian Grebe, a bird whose range extends at its southern margins to Scotland. The Fieldfare and Redwing - birds that are familiar as winter visitors to bird tables and gardens in the north-east but that breed only locally in parts of Scotland - are also suffering a downturn in numbers.

The models used to explore these trends are the same models that have been used to predict long term changes in all bird species across Europe; Durham's ornithological expert Brian Huntley has compiled 'A Climatic Atlas of European Breeding Birds' to map potential changes in distribution of all of the continent's regularly occurring nesting birds. His work shows the need for urgent action on climatic change to avoid calamitous impacts on birds.

The new work has important implications for predicting future trends. Researchers can now look at what has happened in the past to help predict the future species and numbers of birds in Britain.

Southern birds flourishing in the warmer weather:
Little egret
Cetti's warbler
Cirl bunting
Dartford warbler

Northern birds dwindling in the warmer weather:
Redwing
Temminck's stint
Purple sandpiper
Shore lark
Snowy owl

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